Dietary inositol hexakisphosphate, but not myo-inositol, clearly improves hypercholesterolemia in rats fed casein-type amino acid mixtures and 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane.
We examined the effects of inositol hexakisphosphate (IP6) and myo-inositol on high cholesterol in rats. In our study, we found that dietary IP6 effectively reduced increased cholesterol levels caused by a specific chemical exposure, while myo-inositol did not show significant benefits.
Additionally, IP6 also contributed to body weight gain, regardless of other dietary factors. Overall, while both inositol types helped prevent fatty liver, only IP6 demonstrated a clear advantage in managing hypercholesterolemia.
Read More
9
Inositol boosts growth and health
Inositol Inclusion Affects Growth, Body Composition, Antioxidant Performance, and Lipid Metabolism of Largemouth Bass ().
We explored how inositol affects growth performance and cholesterol levels in largemouth bass through a systematic diet study. By preparing six different diets with varying inositol concentrations, we fed the fish for eight weeks and closely monitored their progress. The results showed that our group consuming 250 mg/kg of inositol enjoyed significantly better weight gain, growth rates, and feed efficiency compared to the control group.
Interestingly, as we increased the inositol levels, we noticed a rise in serum triglycerides and cholesterol, particularly peaking in the 250 mg/kg group. It appeared that while inositol helped improve overall growth, it also influenced cholesterol levels in a complex way. However, the high-density lipoprotein cholesterol (HDL-C), often considered "good" cholesterol, remained unaffected across all treatment groups.
Furthermore, our analysis revealed that inositol supplementation not only reduced fat deposition in the liver but also enhanced the fish's antioxidant capacity by lowering harmful enzymes and increasing beneficial antioxidant markers. This suggests that while inositol modified cholesterol dynamics, it also supported the general health and performance of the fish.
Overall, the findings indicate that dietary inositol can significantly improve growth and antioxidant capacity in largemouth bass, with an optimal dosage around 250 mg/kg to harness these benefits effectively.
Read More
9
D--Inositol reduces cholesterol levels
D--Inositol facilitates adiponectin biosynthesis and activates the AMPKα/PPARs pathway to inhibit high-fat diet-induced obesity and liver lipid deposition.
We examined how D--Inositol (DCI), a natural compound found in many living organisms, influences high cholesterol and obesity, especially when combined with a high-fat diet. In our study involving mice over a 12-week period, we observed that DCI supplementation led to noticeable reductions in body weight, triglycerides, total cholesterol, insulin, and fasting glucose levels when given at doses of 50 and 100 mg per kg daily.
The findings were encouraging as DCI not only diminished body weight but also helped lower fat accumulation in the liver and fat tissue. Importantly, we noted a significant increase in serum adiponectin levels, a beneficial hormone linked to improved lipid metabolism. This increase was accompanied by enhanced activity of adiponectin receptors in the liver, which play a key role in regulating fat and energy metabolism.
Additionally, DCI was shown to activate a critical pathway involving AMPKα and PPARs, further promoting healthy fat management in the body. These results suggest that DCI could be a valuable ally in addressing cholesterol and obesity issues, potentially through its influence on adiponectin synthesis and its related metabolic pathways.
Read More
Most Useful Reviews
10
Significant ferritin reduction
8 people found this helpful
This product helped me effectively reduce my ferritin levels, and my body’s inflammation vastly improved without affecting my sleep. Previously, I was troubled for two weeks by high ferritin levels that led to unrestful nights, even landing me in the emergency room. This product helps me absorb iron effectively, preventing bad retention that causes inflammation.
Read More
9
Pleasant ferritin decrease
4 people found this helpful
A wonderful product I bought for my mother, whose ferritin was high at 223. After three months of usage, her levels dropped to 157. With continued use, everything should return to normal.
Read More
9
Effective iron chelation
3 people found this helpful
I wasn't sure what this product would do, but I hoped it would support my immune system. It was challenging to take the required amount since it must be on an empty stomach. I purchased it again due to high iron levels, taking it at night. One month later, my iron had significantly lowered! I believe this supplement could effectively remove iron from my system and help with heavy metal build-up.
We explored how inositol affects growth performance and cholesterol levels in largemouth bass through a systematic diet study. By preparing six different diets with varying inositol concentrations, we fed the fish for eight weeks and closely monitored their progress. The results showed that our group consuming 250 mg/kg of inositol enjoyed significantly better weight gain, growth rates, and feed efficiency compared to the control group.
Interestingly, as we increased the inositol levels, we noticed a rise in serum triglycerides and cholesterol, particularly peaking in the 250 mg/kg group. It appeared that while inositol helped improve overall growth, it also influenced cholesterol levels in a complex way. However, the high-density lipoprotein cholesterol (HDL-C), often considered "good" cholesterol, remained unaffected across all treatment groups.
Furthermore, our analysis revealed that inositol supplementation not only reduced fat deposition in the liver but also enhanced the fish's antioxidant capacity by lowering harmful enzymes and increasing beneficial antioxidant markers. This suggests that while inositol modified cholesterol dynamics, it also supported the general health and performance of the fish.
Overall, the findings indicate that dietary inositol can significantly improve growth and antioxidant capacity in largemouth bass, with an optimal dosage around 250 mg/kg to harness these benefits effectively.
Read More
9
Food supplement aids cholesterol management
Effectiveness of a Food Supplement Based on Glucomannan, D-Chiro-Inositol, Blume and Inulin in Patients with Metabolic Syndrome.
We tested the effectiveness of a food supplement combining glucomannan, D-chiro-inositol, blume, and inulin in managing high cholesterol levels among individuals with metabolic syndrome. Fifty-eight participants, each dealing with either type 2 diabetes or impaired glucose tolerance, took this supplement daily for four months alongside their metformin medication.
Over the course of the study, we observed significant improvements in several key health markers. The participants experienced a marked reduction in their body weight and body mass index (BMI). More importantly for those dealing with high cholesterol, the supplement contributed to noteworthy enhancements in their lipid profiles. Levels of total cholesterol reduced significantly, alongside improvements in triglycerides and low-density lipoprotein (LDL).
Our findings suggest that this food supplement may be a beneficial addition to traditional treatments for managing cholesterol levels and other risk factors associated with metabolic syndrome. This study highlights the potential of inositol as part of a multi-ingredient supplement, although the specific effect of inositol alone wasn't isolated.
Read More
9
D--Inositol reduces cholesterol levels
D--Inositol facilitates adiponectin biosynthesis and activates the AMPKα/PPARs pathway to inhibit high-fat diet-induced obesity and liver lipid deposition.
We examined how D--Inositol (DCI), a natural compound found in many living organisms, influences high cholesterol and obesity, especially when combined with a high-fat diet. In our study involving mice over a 12-week period, we observed that DCI supplementation led to noticeable reductions in body weight, triglycerides, total cholesterol, insulin, and fasting glucose levels when given at doses of 50 and 100 mg per kg daily.
The findings were encouraging as DCI not only diminished body weight but also helped lower fat accumulation in the liver and fat tissue. Importantly, we noted a significant increase in serum adiponectin levels, a beneficial hormone linked to improved lipid metabolism. This increase was accompanied by enhanced activity of adiponectin receptors in the liver, which play a key role in regulating fat and energy metabolism.
Additionally, DCI was shown to activate a critical pathway involving AMPKα and PPARs, further promoting healthy fat management in the body. These results suggest that DCI could be a valuable ally in addressing cholesterol and obesity issues, potentially through its influence on adiponectin synthesis and its related metabolic pathways.
Read More
9
IP6 improves cholesterol levels
Dietary inositol hexakisphosphate, but not myo-inositol, clearly improves hypercholesterolemia in rats fed casein-type amino acid mixtures and 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane.
We examined the effects of inositol hexakisphosphate (IP6) and myo-inositol on high cholesterol in rats. In our study, we found that dietary IP6 effectively reduced increased cholesterol levels caused by a specific chemical exposure, while myo-inositol did not show significant benefits.
Additionally, IP6 also contributed to body weight gain, regardless of other dietary factors. Overall, while both inositol types helped prevent fatty liver, only IP6 demonstrated a clear advantage in managing hypercholesterolemia.
Read More
8
Myo-inositol reduces cholesterol levels
Myo-inositol rescued insulin resistance and dyslipidemia in db/db mice.
We wanted to understand how myo-inositol (MI), a compound found in many foods, influences cholesterol levels and overall metabolic health in db/db mice, a commonly used model for type 2 diabetes. Our findings revealed that providing MI significantly reduced high cholesterol and triglyceride levels in these mice, making a noticeable impact on their lipid profiles.
In addition to lowering cholesterol levels, MI improved insulin resistance, suggesting it might offer a dual benefit for those struggling with metabolic disorders. Interestingly, while MI showed promising effects on cholesterol and glucose levels, it did not help with obesity in the treated mice.
Overall, our study highlights myo-inositol as a potential adjunct therapy for managing high cholesterol and related metabolic challenges in diabetes. These results indicate that incorporating this accessible compound into dietary strategies might benefit patients dealing with these issues.
This product helped me effectively reduce my ferritin levels, and my body’s inflammation vastly improved without affecting my sleep. Previously, I was troubled for two weeks by high ferritin levels that led to unrestful nights, even landing me in the emergency room. This product helps me absorb iron effectively, preventing bad retention that causes inflammation.
Read More
9
Pleasant ferritin decrease
4 people found this helpful
A wonderful product I bought for my mother, whose ferritin was high at 223. After three months of usage, her levels dropped to 157. With continued use, everything should return to normal.
Read More
9
Effective iron chelation
3 people found this helpful
I wasn't sure what this product would do, but I hoped it would support my immune system. It was challenging to take the required amount since it must be on an empty stomach. I purchased it again due to high iron levels, taking it at night. One month later, my iron had significantly lowered! I believe this supplement could effectively remove iron from my system and help with heavy metal build-up.
Read More
9
Improved immune support
3 people found this helpful
The best quality product from Jarrow formulas. I use it to manage insulin resistance and lower high inflammatory ferritin levels as it binds and removes iron. It can be taken for up to six months for optimal results. Used alongside Berberine, it significantly lowers blood sugar levels. My patients report reductions from 7 to 5, and from 8 to 6, showing excellent results.
Read More
9
Cholesterol management
2 people found this helpful
I suffer from chronic dyslipidaemia. I have used this product for over five years, consistently keeping my triglyceride and cholesterol levels at an acceptable level.
High cholesterol, or hyperlipidemia, is a medical condition characterized by an elevated level of cholesterol in the bloodstream. Cholesterol is a waxy, fat-like substance that’s essential for building healthy cells, but too much of it can lead to serious health issues, including heart disease and stroke. Cholesterol is carried through the blood by lipoproteins, with two main types being low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL, often referred to as "bad" cholesterol, can lead to the buildup of plaque in the arteries, while HDL, known as "good" cholesterol, helps carry cholesterol away from the arteries and back to the liver.
Factors contributing to high cholesterol can include poor diet, lack of exercise, obesity, smoking, and genetic predisposition. Regular health screenings are crucial, as high cholesterol often presents no overt symptoms. Maintaining a heart-healthy diet rich in fruits, vegetables, whole grains, and healthy fats, coupled with regular physical activity and avoiding tobacco, can help manage cholesterol levels effectively. In some cases, medications may be necessary to control high cholesterol, so consulting with a healthcare provider is key for tailored advice.
Inositol is a naturally occurring sugar alcohol that plays a crucial role in cellular signaling and the structural integrity of cell membranes. It is a member of the B-vitamin complex and exists in several forms, with myo-inositol being the most prevalent in the human body. Inositol is found in various foods, including fruits, beans, grains, and nuts, and it can also be synthesized by the body from glucose. It is often marketed as a supplement for various health benefits, including mental health support, particularly for conditions like anxiety and depression, and is studied for its potential role in managing polycystic ovary syndrome (PCOS).
Research suggests that inositol may help in alleviating symptoms associated with these health issues by enhancing insulin sensitivity and regulating hormonal balance. While it is generally considered safe for consumption, individuals should consult with healthcare professionals before starting any new supplement regimen, especially if they have existing health conditions or are taking other medications. As with any supplement, the effectiveness can vary from person to person, and understanding the underlying scientific evidence can guide informed choices.
Inositol, a carbohydrate that belongs to the B-vitamin family, has been studied for various health benefits, but its effects on cholesterol levels are still a topic of research. Some studies suggest that inositol, particularly in the form of inositol hexaphosphate (IP6), may have a positive effect on lipid profiles by potentially lowering total cholesterol and triglyceride levels. However, the evidence remains inconclusive, and more extensive clinical trials are needed to establish a definitive link between inositol supplementation and cholesterol management.
If you're considering inositol for cholesterol management, it’s essential to consult with a healthcare provider first. While inositol is generally considered safe, it is crucial to approach any supplement with caution, especially if you have pre-existing health conditions or are taking medications that affect cholesterol levels. Maintaining a healthy lifestyle, including a balanced diet and regular exercise, remains the most effective approach to managing cholesterol levels.
When it comes to managing high cholesterol levels through supplementation, the timeline for seeing results can vary significantly among users. Some reviews indicate that users have noted improvements in their ferritin levels—a marker related to cholesterol and iron levels—after around three months of consistent use. For instance, one user's mother saw her ferritin drop from 223 to 157 after three months of taking the supplement Read Review. Others have reported different outcomes but often mention that a sustained period of usage is essential; one individual mentioned a two-month timeline but highlighted the necessity of a balanced diet alongside supplementation for optimal results Read Review.
Additionally, while some users have experienced gradual improvements in their cholesterol profiles over four months Read Review, there are also instances where users reported no significant changes in their lab results even after considerable time Read Review. Hence, it appears that while three to four months is a common timeframe reported by many users for seeing results, individual experiences can vary widely based on various factors, such as diet, lifestyle, and personal health conditions.
Myo-inositol and D-chiro-inositol have shown potential in managing high cholesterol levels, particularly in individuals with metabolic conditions such as type 2 diabetes and PCOS. Multiple studies indicate that combining these forms of inositol with other nutrients can lead to significant reductions in total cholesterol and low-density lipoprotein (LDL) levels. For instance, one study found that a combination involving myo-inositol, D-chiro-inositol, and other ingredients resulted in noted improvements in lipid profiles among participants with metabolic syndrome after four months of supplementation [3]. Another investigation reported favorable changes in cholesterol levels in patients with type 2 diabetes after a combination therapy of these inositols was administered [4].
However, it's important to note that while myo-inositol and D-chiro-inositol present promising potential as adjunct therapies for high cholesterol, their specific effects in isolation are less clearly defined. For instance, one study mentioned that while improvements in cholesterol levels were observed with combination therapies, the isolated effects of inositol on cholesterol management require further investigation to draw more definitive conclusions [7]. Alongside these findings, the complexity of formulations in various studies makes it challenging to ascertain inositol's distinct contribution to cholesterol reduction [8]. In summary, while the evidence suggests a beneficial role of inositol in cholesterol management, further targeted research would be beneficial to fully understand its effectiveness when used alone.
Based on user reviews, many individuals report significant improvements in their ferritin levels and overall inflammation after using the supplement. For example, one user noticed a reduction in their ferritin from 575 to 515 in just three months, leading them to highly recommend the product Read Review. Another user experienced a drop from 146 to 93 after four months of consistent use Read Review. Additionally, stories from users indicate improved management of health conditions like insulin resistance, where one reported decreased blood sugar levels in conjunction with the supplement Read Review.
It’s worth noting that while many users have reported positive results, such experiences can vary widely. Some users have not seen significant changes in their laboratory results even after consistent use Read Review. This highlights the importance of individual health profiles, dietary habits, and the duration of use, all of which can influence the effects of the supplement. Therefore, while many find success, results can be unique and may require patience and ongoing evaluation.
Based on user reviews, many individuals have reported positive outcomes when combining this supplement with other products specifically for managing high cholesterol and related health issues. One user noted that using this supplement alongside Berberine significantly helped lower blood sugar levels and manage insulin resistance, with measurable reductions in their patients' readings Read Review. Another user also highlighted improvements in their health by using this supplement effectively, mentioning its capacity to bind and remove excess iron, which is beneficial in managing inflammatory conditions Read Review.
However, it’s important to note that some users reported discrepancies in their results when combining this supplement with other products. For example, one user indicated that the supplement should be taken separately from all other supplements, maintaining an interval of 3-4 hours, to ensure optimal absorption and effectiveness Read Review. This suggests that while many have found success in combining supplements, users may need to monitor their intake schedules to avoid possible interactions and achieve the desired outcomes in managing high cholesterol levels.
9
Pleasant ferritin decrease
4 people found this helpful
A wonderful product I bought for my mother, whose ferritin was high at 223. After three months of usage, her levels dropped to 157. With continued use, everything should return to normal.
6
Iron level drop
I tried this due to high iron levels in my blood, and it worked. With the right diet, my levels dropped slightly.
7.5
Notable ferritin decrease
6 people found this helpful
I started taking this after finding high ferritin levels. I aimed to eliminate the inflammatory factor and drive iron into my cells. After four months, my ferritin levels decreased from 146 to 93. However, it did wash out some calcium too.
2
Need for research
I bought IP6 to manage high ferritin but have not seen improvements in my lab results. I need to research it further to understand its effects better.
7.5
Notable ferritin drop
2 people found this helpful
This product seems to be bringing down my ferritin levels. I discovered two years ago my ferritin was 575, and despite my GP's lack of concern, I grew worried. After starting this product three months before my annual check-up, my latest lab test showed a drop to 515. I plan to continue using it and have purchased more. Highly recommend it!
7.5
Good blood sugar results
10 people found this helpful
This company offers the best quality. I bought for my mother to manage insulin resistance and reduce sugar levels as well as high inflammatory ferritin. Our doctor prescribed this drug. He said it binds and removes iron. After three months, her sugar levels decreased from 7 to 5. She finds it palatable and, as advised by the doctor, adheres to the diet. A useful product with great results; we've ordered a second batch.
9
Improved immune support
3 people found this helpful
The best quality product from Jarrow formulas. I use it to manage insulin resistance and lower high inflammatory ferritin levels as it binds and removes iron. It can be taken for up to six months for optimal results. Used alongside Berberine, it significantly lowers blood sugar levels. My patients report reductions from 7 to 5, and from 8 to 6, showing excellent results.
7.5
Effective inflammation reduction
13 people found this helpful
This drug is excellent for reducing inflammation and lowering ferritin levels within the cells. IP-6 should be taken separately from all other supplements, maintaining an interval of 3-4 hours. I give my husband this to reduce high ferritin post-COVID, taking 2 capsules 30-40 minutes before lunch. Be healthy!
9
Food supplement aids cholesterol management
Effectiveness of a Food Supplement Based on Glucomannan, D-Chiro-Inositol, Blume and Inulin in Patients with Metabolic Syndrome.
We tested the effectiveness of a food supplement combining glucomannan, D-chiro-inositol, blume, and inulin in managing high cholesterol levels among individuals with metabolic syndrome. Fifty-eight participants, each dealing with either type 2 diabetes or impaired glucose tolerance, took this supplement daily for four months alongside their metformin medication.
Over the course of the study, we observed significant improvements in several key health markers. The participants experienced a marked reduction in their body weight and body mass index (BMI). More importantly for those dealing with high cholesterol, the supplement contributed to noteworthy enhancements in their lipid profiles. Levels of total cholesterol reduced significantly, alongside improvements in triglycerides and low-density lipoprotein (LDL).
Our findings suggest that this food supplement may be a beneficial addition to traditional treatments for managing cholesterol levels and other risk factors associated with metabolic syndrome. This study highlights the potential of inositol as part of a multi-ingredient supplement, although the specific effect of inositol alone wasn't isolated.
8
Inositol and cholesterol management
Combined Inositols, α-Lactalbumin, Gymnema Sylvestre and Zinc Improve the Lipid Metabolic Profile of Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial.
This study aimed to explore how a combination of myo-inositol and d-chiro-inositol, along with α-lactalbumin, Gymnema sylvestre, and zinc, impacts cholesterol levels in patients with type 2 diabetes mellitus (T2DM).
We evaluated 75 participants who were randomly assigned to either the supplement group or a placebo group. While we found no significant improvements in blood glucose levels between the two groups overall, the results for cholesterol were more promising.
After three months of supplementation, those taking the combination of nutrients experienced a noticeable reduction in total cholesterol and LDL (or bad cholesterol) levels. In a subgroup of patients who kept their diabetes medications unchanged, cholesterol improvements continued to show after six months.
Additionally, members of the supplement group also saw better weight management and enhancements in their HDL (good cholesterol) and triglyceride levels after three months. These findings suggest that combining these specific nutrients could be beneficial in managing cholesterol levels for those with T2DM.
7
Inositol's cholesterol effects unclear
Comparison of Clinical, Metabolic and Hormonal Effects of Metformin Versus Combined Therapy of Metformin With Myoinositol Plus D-Chiro-Inositol in Women With Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial.
We explored the effects of combining metformin with two forms of inositol—myoinositol and D-chiro-inositol—on high cholesterol levels in women with polycystic ovary syndrome (PCOS). This study involved 72 participants who were randomly assigned to either metformin alone or the combination therapy for six months.
While we did observe significant improvements in other areas, such as cycle regularity and various hormonal levels, the specific impact of inositol on cholesterol was less clear. For instance, the combination therapy resulted in notable changes in average cholesterol and other metabolic parameters, but it’s important to highlight that the isolated effect of inositol on cholesterol was not explicitly measured.
Our findings suggest that while there are some benefits to this combined treatment, further research is necessary to fully understand how effective inositol alone might be on cholesterol management in women with PCOS.
8
Nutraceutical improves cholesterol management
An Evaluation of a Nutraceutical with Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients with Fasting Dysglycemia.
We enrolled 148 patients experiencing issues with high fasting glucose levels and glucose tolerance to explore the effects of a nutraceutical combination containing Berberine, Curcumin, Inositol, Banaba, and Chromium Picolinate. Over three months, participants were divided into two groups, with one taking the nutraceutical and the other a placebo. This randomized, double-blind study helped ensure the results were reliable and unbiased.
Our findings indicated that the nutraceutical combination led to improvements in metrics related to blood sugar levels and cholesterol. Specifically, we noted reductions in fasting plasma glucose, glycated hemoglobin, and total cholesterol levels. However, while inositol was one of the ingredients, the complex nature of the combination makes it difficult to isolate its individual effect on cholesterol reduction specifically.
Overall, it seems that the nutraceutical can positively impact metabolic health and may assist those with dysglycemia in improving their cholesterol levels. As we sift through the results, the potential benefits of using inositol in this blend point towards a promising avenue in managing cholesterol, though further research would be necessary to clarify its distinct role.
References
Long L, Huang Q, Song T, Dai Z. Myo-inositol rescued insulin resistance and dyslipidemia in db/db mice. J Appl Biomed. 2024;22:74. 10.32725/jab.2024.009
Xu Y, Gong Y, Li S, Zhou Y, Ma Z, et al. Inositol Inclusion Affects Growth, Body Composition, Antioxidant Performance, and Lipid Metabolism of Largemouth Bass (). Aquac Nutr. 2024;2024:9944159. 10.1155/2024/9944159
Citarrella R, Chianetta R, Amodeo S, Mirarchi L, Licata A, et al. Effectiveness of a Food Supplement Based on Glucomannan, D-Chiro-Inositol, Blume and Inulin in Patients with Metabolic Syndrome. Nutrients. 2024;16. 10.3390/nu16020249
Nani A, Bertuzzi F, Meneghini E, Mion E, Pintaudi B. Combined Inositols, α-Lactalbumin, Gymnema Sylvestre and Zinc Improve the Lipid Metabolic Profile of Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial. J Clin Med. 2023;12. 10.3390/jcm12247650
Tutunchi H, Arefhosseini S, Ebrahimi-Mameghani M. Clinical effectiveness of α-lipoic acid, myo-inositol and propolis supplementation on metabolic profiles and liver function in obese patients with NAFLD: A randomized controlled clinical trial. Clin Nutr ESPEN. 2023;54:412. 10.1016/j.clnesp.2023.02.016
Yang Q, Zhang Y, Li L, Li J, Li Y, et al. D--Inositol facilitates adiponectin biosynthesis and activates the AMPKα/PPARs pathway to inhibit high-fat diet-induced obesity and liver lipid deposition. Food Funct. 2022;13:7192. 10.1039/d2fo00869f
Bahadur A, Arora H, Ravi AK, Naithani M, Bahurupi Y, et al. Comparison of Clinical, Metabolic and Hormonal Effects of Metformin Versus Combined Therapy of Metformin With Myoinositol Plus D-Chiro-Inositol in Women With Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial. Cureus. 2021;13:e15510. 10.7759/cureus.15510
Derosa G, D'Angelo A, Vanelli A, Maffioli P. An Evaluation of a Nutraceutical with Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients with Fasting Dysglycemia. Diabetes Metab Syndr Obes. 2020;13:653. 10.2147/DMSO.S232791
Choi MS, Lee MK, Jung UJ, Kim HJ, Do GM, et al. Metabolic response of soy pinitol on lipid-lowering, antioxidant and hepatoprotective action in hamsters fed-high fat and high cholesterol diet. Mol Nutr Food Res. 2009;53:751. 10.1002/mnfr.200800241
Okazaki Y, Katayama T. Dietary inositol hexakisphosphate, but not myo-inositol, clearly improves hypercholesterolemia in rats fed casein-type amino acid mixtures and 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane. Nutr Res. 2008;28:714. 10.1016/j.nutres.2008.07.003